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Journal Articles with IREMB affiliation published (in print) in 2024:

Strecker J, Wachten T, Neumaier B, Spahn I. Radiochemical isolation of ⁴⁵Ti using ion chromatography. Journal of Radioanalytical and Nuclear Chemistry 2024. https://doi.org/10.1007/s10967-023-09270-z

Endepols H, Anglada-Huguet M, Mandelkow E, Neumaier B, Mandelkow EM, Drzezga A. Fragmentation of functional resting state brain networks in a transgenic mouse model of tau pathology: A metabolic connectivity study using [¹⁸F]FDG-PET. Experimental Neurology 2024, 372, 114632. https://doi.org/10.1016/j.expneurol.2023.114632

Filss CP, Cramer J, Löher S, Lohmann P, Stoffels G, Stegmayr C, Kocher M, Heinzel A, Galldiks N, Wittsack HJ, Sabel M, Neumaier B, Scheins J, Shah NJ, Meyer PT, Mottaghy FM, Langen KJ. Assessment of Brain Tumour Perfusion Using Early-Phase ¹⁸F-FET PET: Comparison with Perfusion-Weighted MRI. Molecular Imaging and Biology 2024, 26(1), 36-44. https://doi.org/10.1007/s11307-023-01861-2

Humpert S, Schneider D, Lang M, Schulze A, Neumaier F, Holschbach M, Bier D, Neumaier B. Radiosynthesis and In Vitro Evaluation of [¹¹C]tozadenant as Adenosine A_2A Receptor Radioligand. Molecules 2024, 29(5), 1089. https://doi.org/10.3390/molecules29051089

Bertram J, Neumaier F, Zlatopolskiy BD, Neumaier B. Desmethyl SuFEx-IT: SO₂F₂-Free Synthesis and Evaluation as a Fluorosulfurylating Agent. Journal of Organic Chemistry 2024, 89(6), 3821-3833. https://doi.org/10.1021/acs.joc.3c02643

Schmidt P, Lindemeyer J, Raut P, Schütz M, Saniternik S, Jönsson J, Endepols H, Fischer T, Quaas A, Schlößer HA, Thelen M, Grüll H. Multiparametric Characterization of the DSL-6A/C1 Pancreatic Cancer Model in Rats. Cancers 2024, 16(8), 1535. https://doi.org/10.3390/cancers16081535

Blaschke SJ, Rautenberg N, Endepols H, Jendro A, Konrad J, Vlachakis S, Wiedermann D, Schroeter M, Hoffmann B, Merkel R, Marklund N, Fink, GR, Rueger MA. Early Blood–Brain Barrier Impairment as a Pathological Hallmark in a Novel Model of Closed-Head Concussive Brain Injury (CBI) in Mice. International Journal of Molecular Sciences 2024, 25(9), 4837. https://doi.org/10.3390/ijms25094837

Humpert S, Schneider D, Bier D, Schulze A, Neumaier F, Neumaier B, Holschbach M. 8-Bicycloalkyl-CPFPX derivatives as potent and selective tools for in vivo imaging of the A₁ adenosine receptor. European Journal of Medicinal Chemistry 2024, 271, 116380. https://doi.org/10.1016/j.ejmech.2024.116380

Doppler CEJ, Seger A, Farrher E, Régio Brambilla C, Hensel L, Filss CP, Hellmich M, Gogishvili A, Shah NJ, Lerche CW, Neumaier B, Langen KJ, Fink GR, Sommerauer M. Glutamate Signaling in Patients With Parkinson Disease With REM Sleep Behavior Disorder. Neurology 2024, 102(9), e209271. https://doi.org/10.1212/wnl.0000000000209271

Bischof GN, Brendel M, Barthel H, Theis H, Barbe M, Bartenstein P, Claasen J, Danek A, Höglinger G, Levin J, Marek K, Neumaier B, Palleis C, Patt M, Rullmann M, Saur D, Schroeter ML, Seibyl J, Song M, Stephens A, Sabri O, Drzezga A, van Eimeren T; German Imaging Initiative for Tauopathies. Improved Tau PET SUVR Quantification in 4-Repeat Tau Phenotypes with [¹⁸F]PI-2620. Journal of Nuclear Medicine 2024, 65(6), 952-955. https://doi.org/10.2967/jnumed.123.265930

Gröner B, Hoffmann C, Endepols H, Urusova EA, Brugger M, Neumaier F, Timmer M, Neumaier B, Zlatopolskiy BD. Radiosynthesis and Preclinical Evaluation of m-[¹⁸F]FET and [¹⁸F]FET-OMe as Novel [¹⁸F]FET Analogs for Brain Tumor Imaging.Molecular Pharmaceutics 2024, 21(6), 2795-2812. https://doi.org/10.1021/acs.molpharmaceut.3c01215

Endepols H, Apetz, N, Vieth L, Lesser C, Schulte-Holtey L, Neumaier B, Drzezga A. Cerebellar Metabolic Connectivity during Treadmill Walking before and after Unilateral Dopamine Depletion in Rats. International Journal of Molecular Sciences 2024, 25(16), 8617. https://doi.org/10.3390/ijms25168617

Cologni R, Holschbach M, Schneider D, Bier D, Schulze A, Stegmayr C, Endepols H, Ermert J, Neumaier F, Neumaier B. Preparation and Preclinical Evaluation of ¹⁸F-Labeled Olutasidenib Derivatives for Non-Invasive Detection of Mutated Isocitrate Dehydrogenase 1 (mIDH1). Molecules 2024, 29(16), 3939. https://doi.org/10.3390/molecules29163939

Journal Articles with IREMB affiliation published (electronically) in 2024:

Paß T, Ricke KM, Hofmann P, Chowdhury RS, Nie Y, Chinnery P, Endepols H, Neumaier B, Carvalho A, Rigoux L, Steculorum SM, Prudent J, Riemer T, Aswendt M, Liss B, Brachvogel B, Wiesner RJ. Preserved striatal innervation maintains motor function despite severe loss of nigral dopaminergic neurons. Brain 2024. https://doi.org/10.1093/brain/awae089

Preprints with IREMB affiliation published (electronically) in 2024:

Kononenko N, Tutas J, Tolve M, Özer-Yildiz E, Ickert L, Klein I, Hosseini M, Liebsch F, Dethloff F, Giavalisco P, Endepols H, Georgomanolis T, Neumaier B, Drzezga A, Daun S, Schwarz G, Thorens B, Gatto G, Frezza C. Autophagy regulator ATG5 preserves cerebellar function by safeguarding its glycolytic activity. Research Square 2024. https://doi.org/10.21203/rs.3.rs-3921650/v1

Journal Articles with IREMB affiliation published (in print) in 2023:

Hoffmann C, Kolks N, Smets D, Haseloer A, Gröner B, Urusova EA, Endepols H, Neumaier F, Ruschewitz U, Klein A, Neumaier B, Zlatopolskiy BD. Next Generation Copper Mediators for the Efficient Production of 18F-Labeled Aromatics. Chemistry 2023, 29(2), e202202965. https://doi.org/10.1002/chem.202202965 

Neumaier F, Zlatopolskiy BD, Neumaier B. Mutated Isocitrate Dehydrogenase (mIDH) as Target for PET Imaging in Gliomas. Molecules 2023, 28(7), 2890. https://doi.org/10.3390/molecules28072890 

Willuweit A, Humpert S, Schöneck M, Endepols H, Burda N, Gremer L, Gering I, Kutzsche J, Shah NJ, Langen KJ, Neumaier B, Willbold D, Drzezga A. Evaluation of the 18F-labeled analog of the therapeutic all-D-enantiomeric peptide RD2 for amyloid β imaging. European Journal of Pharmaceutical Sciences 2023, 184, 106421. https://doi.org/10.1016/j.ejps.2023.106421 

Anglada-Huguet M, Endepols H, Sydow A, Hilgers R, Neumaier B, Drzezga A, Kaniyappan S, Mandelkow E, Mandelkow EM. Reversal of Tau-Dependent Cognitive Decay by Blocking Adenosine A1 Receptors: Comparison of Transgenic Mouse Models with Different Levels of Tauopathy. International Journal of Molecular Sciences 2023, 24(11), 9260. https://doi.org/10.3390/ijms24119260 

Couttas TA, Boost C, Pahlisch F, Sykorova EB, Leweke JE, Koethe D, Endepols H, Rohleder C, Leweke FM. Simultaneous Assessment of Serum Levels and Pharmacologic Effects of Cannabinoids on Endocannabinoids and N-Acylethanolamines by Liquid Chromatography-Tandem Mass Spectrometry. Cannabis and Cannabinoid Research 2023, 8(4), 657-669. https://doi.org/10.1089/can.2021.0181 

Humpert S, Hoffmann C, Neumaier F, Zlatopolskiy BD, Neumaier B. Validation of analytical HPLC with post-column injection as a method for rapid and precise quantification of radiochemical yields. Journal of Chromatography B 2023, 1228, 123847. https://doi.org/10.1016/j.jchromb.2023.123847 

Goßen J, Ribeiro RP, Bier D, Neumaier B, Carloni P, Giorgetti A, Rossetti G. AI-based identification of therapeutic agents targeting GPCRs: introducing ligand type classifiers and systems biology. Chemical Science 2023, 14(32), 8651-8661. https://doi.org/10.1039%2Fd3sc02352d 

Gröner B, Willmann M, Donnerstag L, Urusova EA,Neumaier F, Humpert S, Endepols H, Neumaier B, Zlatopolskiy BD. 7-[18F]Fluoro-8-azaisatoic Anhydrides: Versatile Prosthetic Groups for the Preparation of PET Tracers. Journal of Medicinal Chemistry 2023, 66(17), 12629-12644. https://doi.org/10.1021/acs.jmedchem.3c01310 

Sagalajev B, Lennartz L, Vieth L, Gunawan CT, Neumaier B, Drzezga A, Visser-Vandewalle V, Endepols H, Sesia T. TgF344-AD Rat Model of Alzheimer's Disease: Spatial Disorientation and Asymmetry in Hemispheric Neurodegeneration. Journal of Alzheimer's Disease Reports 2023, 7(1), 1085-1094. https://doi.org/10.3233/adr-230038 

Kolks N, Neumaier F, Neumaier B, Zlatopolskiy BD. Preparation of NIn-Methyl-6-[18F]fluoro- and 5-Hydroxy-7-[18F]fluorotryptophans as Candidate PET-Tracers for Pathway-Specific Visualization of Tryptophan Metabolism. International Journal of Molecular Sciences 2023, 24(20), 15251. https://doi.org/10.3390/ijms242015251 

Theis H, Bischof GN, Brüggemann N, Dargvainiene J, Drzezga A, Grüter T, Lewerenz J, Leypoldt F, Neumaier B, Wandinger KP, Ayzenberg I, van Eimeren T. In Vivo Measurement of Tau Depositions in Anti-IgLON5 Disease Using [18F]PI-2620 PET. Neurology 2023, 101(22), e2325-e2330. https://doi.org/10.1212/wnl.0000000000207870 

Journal Articles with IREMB affiliation published (in print) in 2022:

Dietlein F, Kobe C, Vázquez SM, Fischer T, Endepols H, Hohberg M, Reifegerst M, Neumaier B, Schomäcker K, Drzezga AE, Dietlein M. An ⁸⁹Zr-Labeled PSMA Tracer for PET/CT Imaging of Prostate Cancer Patients.Journal of Nuclear Medicine 2022, 63(4), 573-583. https://doi.org/10.2967/jnumed.121.262290

Endepols H, Zlatopolskiy BD, Zischler J, Alavinejad N, Apetz N, Vus S, Drzezga A, Neumaier B. Imaging of cerebral tryptophan metabolism using 7-[¹⁸F]FTrp-PET in a unilateral Parkinsonian rat model.Neuroimage 2022, 247, 118842. https://doi.org/10.1016/j.neuroimage.2021.118842

Endepols H, Anglada-Huguet M, Mandelkow E, Schmidt Y, Krapf P, Zlatopolskiy BD, Neumaier B, Mandelkow EM, Drzezga A. Assessment of the In Vivo Relationship Between Cerebral Hypometabolism, Tau Deposition, TSPO Expression, and Synaptic Density in a Tauopathy Mouse Model: a Multi-tracer PET Study.Molecular Neurobiology 2022, 59(6), 3402-3413. https://doi.org/10.1007/s12035-022-02793-8

Heinzel A, Dedic D, Galldiks N, Lohmann P, Stoffels G, Filss CP, Kocher M, Migliorini F, Dillen KNH, Geisler S, Stegmayr C, Willuweit A, Sabel M, Rapp M, Eble MJ, Piroth M, Clusmann H, Delev D, Bauer EK, Ceccon G, Dunkl V, Rosen J, Tscherpel C, Werner JM, Ruge MI, Goldbrunner R, Hampl J, Weiss Lucas C, Herrlinger U, Maurer GD, Steinbach JP, Mauler J, Worthoff WA, Neumaier B, Lerche C, Fink GR, Shah NJ, Mottaghy FM, Langen KJ. Two Decades of Brain Tumour Imaging with O-(2-[¹⁸F]fluoroethyl)-L-tyrosine PET: The Forschungszentrum Jülich Experience.Cancers (Basel) 2022, 14(14), 3336. https://doi.org/10.3390/cancers14143336

Richter N, David LS, Grothe MJ, Teipel S, Dietlein M, Tittgemeyer M, Neumaier B, Fink GR, Onur OA, Kukolja J. Age and Anterior Basal Forebrain Volume Predict the Cholinergic Deficit in Patients with Mild Cognitive Impairment due to Alzheimer's Disease.Journal of Alzheimer's Disease 2022, 86(1), 425-440. https://doi.org/10.3233/jad-210261

Vázquez SM, Endepols H, Fischer T, Tawadros SG, Hohberg M, Zimmermanns B, Dietlein F, Neumaier B, Drzezga A, Dietlein M, Schomäcker K. Translational Development of a Zr-89-Labeled Inhibitor of Prostate-specific Membrane Antigen for PET Imaging in Prostate Cancer.Molecular Imaging and Biology, 2022, 24(1), 115-125. https://doi.org/10.1007/s11307-021-01632-x

von Eugen K, Endepols H, Drzezga A, Neumaier B, Güntürkün O, Backes H, Ströckens F. Avian neurons consume three times less glucose than mammalian neurons.Current Biology 2022, 32(19), 4306-4313.e4. https://doi.org/10.1016/j.cub.2022.07.070

Walter HL, Pikhovych A, Endepols H, Rotthues S, Bärmann J, Backes H, Hoehn M, Wiedermann D, Neumaier B, Fink GR, Rueger MA, Schroeter M. Transcranial-Direct-Current-Stimulation Accelerates Motor Recovery After Cortical Infarction in Mice: The Interplay of Structural Cellular Responses and Functional Recovery.Neurorehabilitation and Neural Repair 2022, 36(10-11), 701-714. https://doi.org/10.1177/15459683221124116

Walter N, Bertram J, Drewes B, Bahutski V, Timmer M, Schütz MB, Krämer F, Neumaier F, Endepols H, Neumaier B, Zlatopolskiy BD. Convenient PET-tracer production via SuFEx ¹⁸F-fluorination of nanomolar precursor amounts.European Journal of Medicinal Chemistry 2022, 237, 114383. https://doi.org/10.1016/j.ejmech.2022.114383

Journal Articles with IREMB affiliation published (in print) in 2021:

Willmann M, Ermert J, Prante O, Hübner H, Gmeiner P, Neumaier B. Radiosynthesis and evaluation of ¹⁸F-labeled dopamine D₄-receptor ligands.Nuclear Medicine and Biology 2021, 92, 43-52. https://doi.org/10.1016/j.nucmedbio.2020.07.004

Hammes J, Bischof GN, Bohn KP, Onur Ö, Schneider A, Fliessbach K, Hönig MC, Jessen F, Neumaier B, Drzezga A, van Eimeren T. One-Stop Shop: ¹⁸F-Flortaucipir PET Differentiates Amyloid-Positive and -Negative Forms of Neurodegenerative Diseases.Journal of Nuclear Medicine 2021, 62(2), 240-246. https://doi.org/10.2967/jnumed.120.244061

Renk DR, Skraban M, Bier D, Schulze A, Wabbals E, Wedekind F, Neumaier F, Neumaier B, Holschbach M. Design, synthesis and biological evaluation of Tozadenant analogues as adenosine A_2A receptor ligands.European Journal of Medicinal Chemistry 2021, 214, 113214. https://doi.org/10.1016/j.ejmech.2021.113214

Neumaier F, Stoppe C, Veldeman M, Weiss M, Simon T, Hoellig A, Marx G, Clusmann H, Albanna W. Circulatory dipeptidyl peptidase 3 (cDPP3) is a potential biomarker for early detection of secondary brain injury after aneurysmal subarachnoid hemorrhage.Journal of the Neurological Sciences 2021, 422, 117333. https://doi.org/10.1016/j.jns.2021.117333

Apetz N, Paralikar K, Neumaier B, Drzezga A, Wiedermann D, Iyer R, Munns G, Scott E, Timmermann L, Endepols H. Towards chronic deep brain stimulation in freely moving hemiparkinsonian rats: applicability and functionality of a fully implantable stimulation system.Journal of Neural Engineering 2021, 18(3), 036018. https://doi.org/10.1088/1741-2552/abe806

Willmann M, Hegger J, Neumaier B, Ermert J. Radiosynthesis and Biological Evaluation of [¹⁸F]R91150, a Selective 5-HT_2A Receptor Antagonist for PET-Imaging.ACS Medicinal Chemistry Letters 2021, 12(5), 738-744. https://doi.org/10.1021/acsmedchemlett.0c00658

Neumaier F, Kotliar K, Haeren RHL, Temel Y, Lüke JN, Seyam O, Lindauer U, Clusmann H, Hescheler J, Schubert GA, Schneider T, Albanna W. Retinal Vessel Responses to Flicker Stimulation Are Impaired in Ca_v2.3-Deficient Mice - An in-vivo Evaluation Using Retinal Vessel Analysis (RVA).Frontiers in Neurology 2021, 12, 659890. https://doi.org/10.3389/fneur.2021.659890

Humpert S, Omrane MA, Urusova EA, Gremer L, Willbold D, Endepols H, Krasikova RN, Neumaier B, Zlatopolskiy BD. Rapid ¹⁸F-labeling via Pd-catalyzed S-arylation in aqueous medium.Chemical Communications (Cambridge) 2021, 57(29), 3547-3550. https://doi.org/10.1039/d1cc00745a

Bärmann J, Walter HL, Pikhovych A, Endepols H, Fink GR, Rueger MA, Schroeter M. An analysis of the CatWalk XT and a composite score to assess neurofunctional deficits after photothrombosis in mice.Neuroscience Letters 2021, 751, 135811. https://doi.org/10.1016/j.neulet.2021.135811

Dietlein F, Mueller P, Kobe C, Endepols H, Hohberg M, Zlatopolskiy BD, Krapf P, Heidenreich A, Neumaier B, Drzezga A, Dietlein M. [¹⁸F]-JK-PSMA-7 PET/CT Under Androgen Deprivation Therapy in Advanced Prostate Cancer.Molecular Imaging and Biology 2021, 23(2), 277-286. https://doi.org/10.1007/s11307-020-01546-0

Schroeder DC, Popp E, Rohleder C, Vus S, Bethencourt DP, Finke SR, Zlatopolskiy BD, Zischler J, Drzezga A, Herff H, Annecke T, Hucho T, Neumaier B, Böttiger BW, Endepols H. Positron Emission Tomography Imaging of Long-Term Expression of the 18 kDa Translocator Protein After Sudden Cardiac Arrest in Rats.Shock 2021, 55(5), 620-629. https://doi.org/10.1097/shk.0000000000001546

Orlovskaya VV, Craig AS, Fedorova OS, Kuznetsova OF, Neumaier B, Krasikova RN, Zlatopolskiy BD. Production of 6-l-[¹⁸F]Fluoro-m-tyrosine in an Automated Synthesis Module for ¹¹C-Labeling.Molecules 2021, 26(18), 5550. https://doi.org/10.3390/molecules26185550

Hoffmann C, Evcüman S, Neumaier F, Zlatopolskiy BD, Humpert S, Bier D, Holschbach M, Schulze A, Endepols H, Neumaier B. [¹⁸F]ALX5406: A Brain-Penetrating Prodrug for GlyT1-Specific PET Imaging.ACS Chemical Neuroscience 2021, 12(18), 3335-3346. https://doi.org/10.1021/acschemneuro.1c00284

Neumaier F, Zlatopolskiy BD, Neumaier B. Drug Penetration into the Central Nervous System: Pharmacokinetic Concepts and In Vitro Model Systems.Pharmaceutics 2021, 13(10), 1542. https://doi.org/10.3390/pharmaceutics13101542

Neumaier F, Weiss M, Veldeman M, Kotliar K, Wiesmann M, Schulze-Steinen H, Höllig A, Clusmann H, Schubert GA, Albanna W. Changes in endogenous daytime melatonin levels after aneurysmal subarachnoid hemorrhage - Preliminary findings from an observational cohort study.Clinical Neurology and Neurosurgery 2021, 208, 106870. https://doi.org/10.1016/j.clineuro.2021.106870

Meinhardt MW, Pfarr S, Fouquet G, Rohleder C, Meinhardt ML, Barroso-Flores J, Hoffmann R, Jeanblanc J, Paul E, Wagner K, Hansson AC, Köhr G, Meier N, von Bohlen Und Halbach O, Bell RL, Endepols H, Neumaier B, Schönig K, Bartsch D, Naassila M, Spanagel R, Sommer WH. Psilocybin targets a common molecular mechanism for cognitive impairment and increased craving in alcoholism.Science Advances 2021, 7(47), eabh2399. https://doi.org/10.1126/sciadv.abh2399

Krämer F, Gröner B, Hoffmann C, Craig A, Brugger M, Drzezga A, Timmer M, Neumaier F, Zlatopolskiy BD, Endepols H, Neumaier B. Evaluation of 3-l- and 3-d-[¹⁸F]Fluorophenylalanines as PET Tracers for Tumor Imaging.Cancers (Basel) 2021, 13(23), 6030. https://doi.org/10.3390/cancers13236030

Song M, Scheifele M, Barthel H, van Eimeren T, Beyer L, Marek K, Eckenweber F, Palleis C, Kaiser L, Finze A, Kern M, Nitschmann A, Biechele G, Katzdobler S, Bischof G, Hammes J, Jessen F, Saur D, Schroeter ML, Rumpf JJ, Rullmann M, Schildan A, Patt M, Neumaier B, Stephens AW, Rauchmann BS, Perneczky R, Levin J, Classen J, Höglinger GU, Bartenstein P, Boening G, Ziegler S, Villemagne V, Drzezga A, Seibyl J, Sabri O, Brendel M; German Imaging Initiative for Tauopathies (GII4T). Feasibility of short imaging protocols for [¹⁸F]PI-2620 tau-PET in progressive supranuclear palsy.European Journal of Nuclear Medicine and Molecular Imaging 2021, 48(12), 3872-3885. https://doi.org/10.1007/s00259-021-05391-3

Journal Articles with IREMB affiliation published (in print) in 2020:

Dietlein F, Hohberg M, Kobe C, Zlatopolskiy BD, Krapf P, Endepols H, Täger P, Hammes J, Heidenreich A, Neumaier B, Drzezga A, Dietlein M. An ¹⁸F-Labeled PSMA Ligand for PET/CT of Prostate Cancer: First-in-Humans Observational Study and Clinical Experience with ¹⁸F-JK-PSMA-7 During the First Year of Application.Journal of Nuclear Medicine 2020, 61(2), 202-209. https://doi.org/10.2967/jnumed.119.229542

Dietlein F, Kobe C, Hohberg M, Zlatopolskiy BD, Krapf P, Endepols H, Täger P, Hammes J, Heidenreich A, Persigehl T, Neumaier B, Drzezga A, Dietlein M. Intraindividual Comparison of ¹⁸F-PSMA-1007 with Renally Excreted PSMA Ligands for PSMA PET Imaging in Patients with Relapsed Prostate Cancer.Journal of Nuclear Medicine 2020, 61(5), 729-734. https://doi.org/10.2967/jnumed.119.234898

Rohleder C, Pahlisch F, Graf R, Endepols H, Leweke FM. Different pharmaceutical preparations of Δ⁹ -tetrahydrocannabinol differentially affect its behavioral effects in rats.Addiction Biology 2020, 25(3), e12745. https://doi.org/10.1111/adb.12745

Zlatopolskiy BD, Neumaier F, Rüngeler T, Drewes B, Kolks N, Neumaier B. Preparation of a First ¹⁸F-Labeled Agonist for M₁ Muscarinic Acetylcholine Receptors.Molecules 2020, 25(12), 2880. https://doi.org/10.3390/molecules25122880

Craig A, Kolks N, Urusova EA, Zischler J, Brugger M, Endepols H, Neumaier B, Zlatopolskiy BD. Preparation of labeled aromatic amino acids via late-stage ¹⁸F-fluorination of chiral nickel and copper complexes.Chemical Communications (Cambridge) 2020, 56(66), 9505-9508. https://doi.org/10.1039/d0cc02223c

Cui D, Mesaros A, Burdeos G, Voigt I, Giavalisco P, Hinze Y, Purrio M, Neumaier B, Drzezga A, Obata Y, Endepols H, Xu X. Dnmt3a2/Dnmt3L Overexpression in the Dopaminergic System of Mice Increases Exercise Behavior through Signaling Changes in the Hypothalamus.International Journal of Molecular Sciences 2020, 21(17), 6297. https://doi.org/10.3390/ijms21176297

Zlatopolskiy BD, Endepols H, Krasikova RN, Fedorova OS, Ermert J, Neumaier B. ¹¹C- and ¹⁸F-labelled tryptophans as PET-tracers for imaging of altered tryptophan metabolism in age-associated disorders.  Russian Chemical Reviews 2020, 89(9), 879–896. http://dx.doi.org/10.1070/RCR4954

Bier D, Holschbach M, Wedekind F, Sihver W, Drewes B, Schulze A, Neumaier F, Neumaier B, Bauer A. Preparation of 5-[¹³¹I]iodotubercidin for the detection of adenosine kinase.Journal of Radioanalytical and Nuclear Chemistry 2020, 326, 1691–1697. https://doi.org/10.1007/s10967-020-07465-2

Bier D, Schulze A, Holschbach M, Neumaier B, Baumann A. Development and Evaluation of a Versatile Receptor-Ligand Binding Assay Using Cell Membrane Preparations Embedded in an Agarose Gel Matrix and Evaluation with the Human Adenosine A₁ Receptor.Assay and Drug Development Technologies 2020, 18(7), 328-340. https://doi.org/10.1089/adt.2020.991

Beyer L, Nitschmann A, Barthel H, van Eimeren T, Unterrainer M, Sauerbeck J, Marek K, Song M, Palleis C, Respondek G, Hammes J, Barbe MT, Onur Ö, Jessen F, Saur D, Schroeter ML, Rumpf JJ, Rullmann M, Schildan A, Patt M, Neumaier B, Barret O, Madonia J, Russell DS, Stephens AW, Roeber S, Herms J, Bötzel K, Levin J, Classen J, Höglinger GU, Bartenstein P, Villemagne V, Drzezga A, Seibyl J, Sabri O, Brendel M. Early-phase [¹⁸F]PI-2620 tau-PET imaging as a surrogate marker of neuronal injury.European Journal of Nuclear Medicine and Molecular Imaging 2020, 47(12), 2911-2922. https://doi.org/10.1007%2Fs00259-020-04788-w

Richter N, Bischof GN, Dronse J, Nellessen N, Neumaier B, Langen KJ, Drzezga A, Fink GR, van Eimeren T, Kukolja J, Onur OA. Entorhinal Tau Predicts Hippocampal Activation and Memory Deficits in Alzheimer's Disease.Journal of Alzheimer's Disease 2020, 78(4), 1601-1614. https://doi.org/10.3233/jad-200835

Neumaier F, Zlatopolskiy BD, Neumaier B. Nuclear Medicine in Times of COVID-19: How Radiopharmaceuticals Could Help to Fight the Current and Future Pandemics.Pharmaceutics 2020, 12(12), 1247. https://doi.org/10.3390/pharmaceutics12121247

Brandt MR, Vanasschen C, Ermert J, Coenen HH, Neumaier B. ^52g/55Mn-Labelled CDTA-based trimeric complexes as novel bimodal PET/MR probes with high relaxivity.Dalton Transactions 2019,  48(9), 3003-3008. https://doi.org/10.1039/c8dt04996c

Modemann DJ, Zlatopolskiy BD, Urusova EA, Zischler J, Craig A, Ermert J, Guliyev M, Endepols H, Neumaier B. 2-[¹⁸F]Fluorophenylalanine: Synthesis by Nucleophilic ¹⁸F-Fluorination and Preliminary Biological Evaluation. Synthesis 2019, 51(03), 664-676. http://dx.doi.org/10.1055/s-0037-1611370

Woeste MA, Stern S, Raju DN, Grahn E, Dittmann D, Gutbrod K, Dörmann P, Hansen JN, Schonauer S, Marx CE, Hamzeh H, Körschen HG, Aerts JMFG, Bönigk W, Endepols H, Sandhoff R, Geyer M, Berger TK, Bradke F, Wachten D. Species-specific differences in nonlysosomal glucosylceramidase GBA2 function underlie locomotor dysfunction arising from loss-of-function mutations.Journal of Biological Chemistry 2019, 294(11), 3853-3871. https://doi.org/10.1074/jbc.ra118.006311

Apetz N, Kordys E, Simon M, Mang B, Aswendt M, Wiedermann D, Neumaier B, Drzezga A, Timmermann L, Endepols H. Effects of subthalamic deep brain stimulation on striatal metabolic connectivity in a rat hemiparkinsonian model.Disease Models and Mechanisms 2019, 12(5), dmm039065. https://doi.org/10.1242/dmm.039065

Endepols H, Morgenroth A, Zlatopolskiy BD, Krapf P, Zischler J, Richarz R, Muñoz Vásquez S, Neumaier B, Mottaghy FM. Peripheral ganglia in healthy rats as target structures for the evaluation of PSMA imaging agents.BMC Cancer 2019, 19(1), 633. https://doi.org/10.1186/s12885-019-5841-8

Zlatopolskiy BD, Zischler J, Krapf P, Richarz R, Lauchner K, Neumaier B. Minimalist approach meets green chemistry: Synthesis of ¹⁸F-labeled (hetero)aromatics in pure ethanol. Journal of Labelled Compounds and Radiopharmaceuticals 2019, 62(8), 404-410. https://doi.org/10.1002/jlcr.3776               

Zlatopolskiy BD, Endepols H, Krapf P, Guliyev M, Urusova EA, Richarz R, Hohberg M, Dietlein M, Drzezga A, Neumaier B. Discovery of ¹⁸F-JK-PSMA-7, a PET Probe for the Detection of Small PSMA-Positive Lesions.Journal of Nuclear Medicine 2019, 60(6), 817-823. https://doi.org/10.2967/jnumed.118.218495

Hohberg M, Kobe C, Krapf P, Täger P, Hammes J, Dietlein F, Zlatopolskiy BD, Endepols H, Wild M, Neubauer S, Heidenreich A, Neumaier B, Drzezga A, Dietlein M. Biodistribution and radiation dosimetry of [¹⁸F]-JK-PSMA-7 as a novel prostate-specific membrane antigen-specific ligand for PET/CT imaging of prostate cancer.EJNMMI Research 2019, 9(1), 66. https://doi.org/10.1186/s13550-019-0540-7

Richter N, Nellessen N, Dronse J, Dillen K, Jacobs HIL, Langen KJ, Dietlein M, Kracht L, Neumaier B, Fink GR, Kukolja J, Onur OA. Spatial distributions of cholinergic impairment and neuronal hypometabolism differ in MCI due to AD.Neuroimage Clinical 2019, 24, 101978. https://doi.org/10.1016/j.nicl.2019.101978

Hoenig MC, Bischof GN, Onur ÖA, Kukolja J, Jessen F, Fliessbach K, Neumaier B, Fink GR, Kalbe E, Drzezga A, van Eimeren T; Alzheimer’s Disease Neuroimaging Initiative. Level of education mitigates the impact of tau pathology on neuronal function.European Journal of Nuclear Medicine and Molecular Imaging 2019, 46(9), 1787-1795. https://doi.org/10.1007/s00259-019-04342-3

Orlovskaya VV, Modemann DJ, Kuznetsova OF, Fedorova OS, Urusova EA, Kolks N, Neumaier B, Krasikova RN, Zlatopolskiy BD. Alcohol-Supported Cu-Mediated ¹⁸F-Fluorination of Iodonium Salts under "Minimalist" Conditions.Molecules 2019, 24(17), 3197. https://doi.org/10.3390/molecules24173197

Rohleder C, Koethe D, Fritze S, Topor CE, Leweke FM, Hirjak D. Neural correlates of binocular depth inversion illusion in antipsychotic-naïve first-episode schizophrenia patients.European Archives of Psychiatry and Clinical Neuroscience 2019, 269(8), 897-910. https://doi.org/10.1007/s00406-018-0886-2

Zlatopolskiy BD, Zischler J, Schäfer D, Urusova EA, Guliyev M, Bannykh O, Endepols H, Neumaier B. Discovery of 7-[¹⁸F]Fluorotryptophan as a Novel Positron Emission Tomography (PET) Probe for the Visualization of Tryptophan Metabolism in Vivo.Journal of Medicinal Chemistry 2018, 61(1), 189-206. https://doi.org/10.1021/acs.jmedchem.7b01245

Hoenig MC, Bischof GN, Seemiller J, Hammes J, Kukolja J, Onur ÖA, Jessen F, Fliessbach K, Neumaier B, Fink GR, van Eimeren T, Drzezga A. Networks of tau distribution in Alzheimer's disease.Brain 2018, 141(2), 568-581. https://doi.org/10.1093/brain/awx353

Richter N, Beckers N, Onur OA, Dietlein M, Tittgemeyer M, Kracht L, Neumaier B, Fink GR, Kukolja J. Effect of cholinergic treatment depends on cholinergic integrity in early Alzheimer's disease.Brain 2018, 141(3), 903-915.                https://doi.org/10.1093/brain/awx356

Endepols H, Mottaghy FM, Simsekyilmaz S, Bucerius J, Vogt F, Winz O, Richarz R, Krapf P, Neumaier B, Zlatopolskiy BD, Morgenroth A. In vivo Molecular Imaging of Glutamate Carboxypeptidase II Expression in Re-endothelialisation after Percutaneous Balloon Denudation in a Rat Model.Scientific Reports 2018, 8(1), 7411. https://doi.org/10.1038/s41598-018-25863-1    

Hammes J, Hohberg M, Täger P, Wild M, Zlatopolskiy BD, Krapf P, Neumaier B, Schomäcker K, Kobe C, Schmidt M, Dietlein M, Drzezga A. Uptake in non-affected bone tissue does not differ between [¹⁸F]-DCFPyL and [⁶⁸Ga]-HBED-CC PSMA PET/CT.PLoS One 2018, 13(12), e0209613. https://doi.org/10.1371%2Fjournal.pone.0209613

Zischler J, Kolks N, Modemann D, Neumaier B, Zlatopolskiy BD. Alcohol-Enhanced Cu-Mediated Radiofluorination.Chemistry 2017, 23(14), 3251-3256. https://doi.org/10.1002/chem.201604633

Morgenroth A, Vogg AT, Neumaier B, Mottaghy FM, Zlatopolskiy BD. Radioiodinated indomethacin amide for molecular imaging of cyclooxygenase-2 expressing tumors.Oncotarget 2017, 8(11), 18059-18069. https://doi.org/10.18632/oncotarget.15437

Richter N, Michel A, Onur OA, Kracht L, Dietlein M, Tittgemeyer M, Neumaier B, Fink GR, Kukolja J. White matter lesions and the cholinergic deficit in aging and mild cognitive impairment.Neurobiology of Aging 2017, 53, 27-35. https://doi.org/10.1016/j.neurobiolaging.2017.01.012

Dietlein F, Kobe C, Neubauer S, Schmidt M, Stockter S, Fischer T, Schomäcker K, Heidenreich A, Zlatopolskiy BD, Neumaier B, Drzezga A, Dietlein M. PSA-Stratified Performance of ¹⁸F- and ⁶⁸Ga-PSMA PET in Patients with Biochemical Recurrence of Prostate Cancer.Journal of Nuclear Medicine 2017, 58(6), 947-952. https://doi.org/10.2967/jnumed.116.185538

Kordys E, Apetz N, Schneider K, Duncan E, Büschbell B, Rohleder C, Sué M, Drzezga A, Neumaier B, Timmermann L, Endepols H. Motor impairment and compensation in a hemiparkinsonian rat model: correlation between dopamine depletion severity, cerebral metabolism and gait patterns.EJNMMI Research 2017, 7(1), 68. https://doi.org/10.1186/s13550-017-0317-9

Dronse J, Fliessbach K, Bischof GN, von Reutern B, Faber J, Hammes J, Kuhnert G, Neumaier B, Onur OA, Kukolja J, van Eimeren T, Jessen F, Fink GR, Klockgether T, Drzezga A. In vivo Patterns of Tau Pathology, Amyloid-β Burden, and Neuronal Dysfunction in Clinical Variants of Alzheimer's Disease.Journal of Alzheimer's Disease 2017, 55(2), 465-471. https://doi.org/10.3233/jad-160316

Zarrad F, Zlatopolskiy BD, Krapf P, Zischler J, Neumaier B. A Practical Method for the Preparation of ¹⁸F-Labeled Aromatic Amino Acids from Nucleophilic [¹⁸F]Fluoride and Stannyl Precursors for Electrophilic Radiohalogenation.Molecules 2017, 22(12), 2231. https://doi.org/10.3390/molecules22122231

Feni L, Omrane MA, Fischer M, Zlatopolskiy BD, Neumaier B, Neundorf I. Convenient Preparation of ¹⁸F-Labeled Peptide Probes for Potential Claudin-4 PET Imaging.Pharmaceuticals (Basel) 2017, 10(4), 99. https://doi.org/10.3390/ph10040099

Krapf P, Richarz R, Urusova EA,Neumaier B, Zlatopolskiy BD. Seyferth–Gilbert Homologation as a Route to ¹⁸F-Labeled Building Blocks: Preparation of Radiofluorinated Phenylacetylenes and Their Application in PET Chemistry.European Journal of Organic Chemistry 2016, 3, 430-433. https://doi.org/10.1002/ejoc.201501377

Backes H, Walberer M, Ladwig A, Rueger MA, Neumaier B, Endepols H, Hoehn M, Fink GR, Schroeter M, Graf R. Glucose consumption of inflammatory cells masks metabolic deficits in the brain.Neuroimage 2016, 128, 54-62. https://doi.org/10.1016/j.neuroimage.2015.12.044

Rohleder C, Wiedermann D, Neumaier B, Drzezga A, Timmermann L, Graf R, Leweke FM, Endepols H. The Functional Networks of Prepulse Inhibition: Neuronal Connectivity Analysis Based on FDG-PET in Awake and Unrestrained Rats.Frontiers in Behavioral Neuroscience 2016, 10, 148. https://doi.org/10.3389/fnbeh.2016.00148

Schäfer D, Weiß P, Ermert J, Meleán JC, Zarrad F, Neumaier B. Preparation of No-Carrier-Added 6-[¹⁸F]Fluoro-L-tryptophan via Cu-Mediated Radiofluorination.European Journal of Organic Chemistry 2016, 27, 4621-4628. https://doi.org/10.1002/ejoc.201600705

Zischler J, Krapf P, Richarz R, Zlatopolskiy BD, Neumaier B. Automated synthesis of 4-[(18)F]fluoroanisole, [(18)F]DAA1106 and 4-[(18)F]FPhe using Cu-mediated radiofluorination under "minimalist" conditions.Applied Radiation and Isotopes 2016, 115, 133-137. https://doi.org/10.1016/j.apradiso.2016.04.030

Rowe SP, Drzezga A, Neumaier B, Dietlein M, Gorin MA, Zalutsky MR, Pomper MG. Prostate-Specific Membrane Antigen-Targeted Radiohalogenated PET and Therapeutic Agents for Prostate Cancer.Journal of Nuclear Medicine 2016, 57(Suppl 3), 90S-96S. https://doi.org/10.2967/jnumed.115.170175

Bischof GN, Jessen F, Fliessbach K, Dronse J, Hammes J, Neumaier B, Onur O, Fink GR, Kukolja J, Drzezga A, van Eimeren T; Alzheimer's Disease Neuroimaging Initiative. Impact of tau and amyloid burden on glucose metabolism in Alzheimer's disease.Annals of Clinical and Translational Neurology 2016, 3(12), 934-939. https://doi.org/10.1002/acn3.339

Zlatopolskiy BD, Zischler J, Krapf P, Zarrad F, Urusova EA, Kordys E, Endepols H, Neumaier B. Copper-mediated aromatic radiofluorination revisited: efficient production of PET tracers on a preparative scale.Chemistry 2015, 21(15), 5972-9. https://doi.org/10.1002/chem.201405586          

Zlatopolskiy BD, Zischler J, Urusova EA, Endepols H, Kordys E, Frauendorf H, Mottaghy FM, Neumaier B. A Practical One-Pot Synthesis of Positron Emission Tomography (PET) Tracers via Nickel-Mediated Radiofluorination.ChemistryOpen 2015, 4(4), 457-62. https://doi.org/10.1002/open.201500056

Dietlein M, Kobe C, Kuhnert G, Stockter S, Fischer T, Schomäcker K, Schmidt M, Dietlein F, Zlatopolskiy BD, Krapf P, Richarz R, Neubauer S, Drzezga A, Neumaier B. Comparison of [(18)F]DCFPyL and [(68)Ga]Ga-PSMA-HBED-CC for PSMA-PET Imaging in Patients with Relapsed Prostate Cancer.Molecular Imaging and Biology 2015, 17(4), 575-84. https://doi.org/10.1007/s11307-015-0866-0

Schöttle J, Chatterjee S, Volz C, Siobal M, Florin A, Rokitta D, Hinze Y, Dietlein F, Plenker D, König K, Albus K, Heuckmann JM, Rauh D, Franz T, Neumaier B, Fuhr U, Heukamp LC, Ullrich RT. Intermittent high-dose treatment with erlotinib enhances therapeutic efficacy in EGFR-mutant lung cancer.Oncotarget 2015, 6(36), 38458-68. https://doi.org/10.18632/oncotarget.6276

Kobe C, Boellaard R, Wolf J, Kuhnert G, Dietlein M, Neumaier B, Drzezga A, Kahraman D. Developments in oncological positron emission tomography/computed tomography assessment.Journal of Thoracic Disease 2015, 7(12), E637-9. https://doi.org/10.3978/j.issn.2072-1439.2015.12.45

Morgenroth A, Vogg AT, Zlatopolskiy BD, Siluschek M, Oedekoven C, Mottaghy FM. Breaking the invulnerability of cancer stem cells: two-step strategy to kill the stem-like cell subpopulation of multiple myeloma.Molecular Cancer Therapeutics 2014, 13(1), 144-53. https://doi.org/10.1158/1535-7163.mct-13-0240

Zlatopolskiy BD, Krapf P, Richarz R, Frauendorf H, Mottaghy FM, Neumaier B. Synthesis of ¹⁸F-Labelled β-Lactams by Using the Kinugasa Reaction.Chemistry – A European Journal 2014, 20, 4697-4703. https://doi.org/10.1002/chem.201304056

Prante O, Haubner R, Riss P, Neumaier B. Recent trends in pharmaceutical radiochemistry for molecular PET imaging.BioMed Research International 2014, 890540. https://doi.org/10.1155/2014/890540

Richarz R, Krapf P, Zarrad F, Urusova EA, Neumaier B, Zlatopolskiy BD. Neither azeotropic drying, nor base nor other additives: a minimalist approach to (18)F-labeling.Organic and Biomolecular Chemistry 2014, 12(40), 8094-9. https://doi.org/10.1039/c4ob01336k