Journal Articles with IREMB affiliation published (in print) in 2023:

Hoffmann C, Kolks N, Smets D, Haseloer A, Gröner B, Urusova EA, Endepols H, Neumaier F, Ruschewitz U, Klein A, Neumaier B, Zlatopolskiy BD. Next Generation Copper Mediators for the Efficient Production of 18F-Labeled Aromatics. Chemistry 2023, 29(2), e202202965.

Neumaier F, Zlatopolskiy BD, Neumaier B. Mutated Isocitrate Dehydrogenase (mIDH) as Target for PET Imaging in Gliomas. Molecules 2023, 28(7), 2890.

Willuweit A, Humpert S, Schöneck M, Endepols H, Burda N, Gremer L, Gering I, Kutzsche J, Shah NJ, Langen KJ, Neumaier B, Willbold D, Drzezga A. Evaluation of the 18F-labeled analog of the therapeutic all-D-enantiomeric peptide RD2 for amyloid β imaging. European Journal of Pharmaceutical Sciences 2023, 184, 106421.

Anglada-Huguet M, Endepols H, Sydow A, Hilgers R, Neumaier B, Drzezga A, Kaniyappan S, Mandelkow E, Mandelkow EM. Reversal of Tau-Dependent Cognitive Decay by Blocking Adenosine A1 Receptors: Comparison of Transgenic Mouse Models with Different Levels of Tauopathy. International Journal of Molecular Sciences 2023, 24(11), 9260.

Couttas TA, Boost C, Pahlisch F, Sykorova EB, Leweke JE, Koethe D, Endepols H, Rohleder C, Leweke FM. Simultaneous Assessment of Serum Levels and Pharmacologic Effects of Cannabinoids on Endocannabinoids and N-Acylethanolamines by Liquid Chromatography-Tandem Mass Spectrometry. Cannabis and Cannabinoid Research 2023, 8(4), 657-669.

Humpert S, Hoffmann C, Neumaier F, Zlatopolskiy BD, Neumaier B. Validation of analytical HPLC with post-column injection as a method for rapid and precise quantification of radiochemical yields. Journal of Chromatography B 2023, 1228, 123847.

Goßen J, Ribeiro RP, Bier D, Neumaier B, Carloni P, Giorgetti A, Rossetti G. AI-based identification of therapeutic agents targeting GPCRs: introducing ligand type classifiers and systems biology. Chemical Science 2023, 14(32), 8651-8661.

Gröner B, Willmann M, Donnerstag L, Urusova EA, Neumaier F, Humpert S, Endepols H, Neumaier B, Zlatopolskiy BD. 7-[18F]Fluoro-8-azaisatoic Anhydrides: Versatile Prosthetic Groups for the Preparation of PET Tracers. Journal of Medicinal Chemistry 2023, 66(17), 12629-12644.

Sagalajev B, Lennartz L, Vieth L, Gunawan CT, Neumaier B, Drzezga A, Visser-Vandewalle V, Endepols H, Sesia T. TgF344-AD Rat Model of Alzheimer's Disease: Spatial Disorientation and Asymmetry in Hemispheric Neurodegeneration. Journal of Alzheimer's Disease Reports 2023, 7(1), 1085-1094.

Kolks N, Neumaier F, Neumaier B, Zlatopolskiy BD. Preparation of NIn-Methyl-6-[18F]fluoro- and 5-Hydroxy-7-[18F]fluorotryptophans as Candidate PET-Tracers for Pathway-Specific Visualization of Tryptophan Metabolism. International Journal of Molecular Sciences 2023, 24(20), 15251.

Journal Articles with IREMB affiliation published (electronically) in 2023:

Theis H, Bischof GN, Brüggemann N, Dargvainiene J, Drzezga A, Grüter T, Lewerenz J, Leypoldt F, Neumaier B, Wandinger KP, Ayzenberg I, Van Eimeren T. In Vivo Measurement of Tau Depositions in Anti-IgLON5 Disease Using 18F-PI-2620 PET. Neurology 2023, 10.1212/WNL.0000000000207870.

Filss CP, Cramer J, Löher S, Lohmann P, Stoffels G, Stegmayr C, Kocher M, Heinzel A, Galldiks N, Wittsack HJ, Sabel M, Neumaier B, Scheins J, Shah NJ, Meyer PT, Mottaghy FM, Langen KJ. Assessment of Brain Tumour Perfusion Using Early-Phase 18F-FET PET: Comparison with Perfusion-Weighted MRI. Molecular Imaging and Biology 2023.

Preprints with IREMB affiliation published (electronically) in 2023:

Paß T, Ricke KM, Hofmann P, Chowdhury R, Nie Y, Chinnery P, Endepols H, Neumaier B, Carvalho A, Rigoux L, Steculorum S, Prudent J, Riemer T, Aswendt M, Brachvogel B, Wiesner RJ. Preserved striatal innervation and motor function despite severe loss of nigral dopamine neurons following mitochondrial dysfunction induced by mtDNA mutations. bioRxiv 2023.


Journal Articles with IREMB affiliation published (in print) in 2022:

Dietlein F, Kobe C, Vázquez SM, Fischer T, Endepols H, Hohberg M, Reifegerst M, Neumaier B, Schomäcker K, Drzezga AE, Dietlein M. An 89Zr-Labeled PSMA Tracer for PET/CT Imaging of Prostate Cancer Patients. Journal of Nuclear Medicine 2022, 63(4), 573-583.

Endepols H, Zlatopolskiy BD, Zischler J, Alavinejad N, Apetz N, Vus S, Drzezga A, Neumaier B. Imaging of cerebral tryptophan metabolism using 7-[18F]FTrp-PET in a unilateral Parkinsonian rat model. Neuroimage 2022, 247, 118842.

Endepols H, Anglada-Huguet M, Mandelkow E, Schmidt Y, Krapf P, Zlatopolskiy BD, Neumaier B, Mandelkow EM, Drzezga A. Assessment of the In Vivo Relationship Between Cerebral Hypometabolism, Tau Deposition, TSPO Expression, and Synaptic Density in a Tauopathy Mouse Model: a Multi-tracer PET Study. Molecular Neurobiology 2022, 59(6), 3402-3413.

Heinzel A, Dedic D, Galldiks N, Lohmann P, Stoffels G, Filss CP, Kocher M, Migliorini F, Dillen KNH, Geisler S, Stegmayr C, Willuweit A, Sabel M, Rapp M, Eble MJ, Piroth M, Clusmann H, Delev D, Bauer EK, Ceccon G, Dunkl V, Rosen J, Tscherpel C, Werner JM, Ruge MI, Goldbrunner R, Hampl J, Weiss Lucas C, Herrlinger U, Maurer GD, Steinbach JP, Mauler J, Worthoff WA, Neumaier B, Lerche C, Fink GR, Shah NJ, Mottaghy FM, Langen KJ. Two Decades of Brain Tumour Imaging with O-(2-[18F]fluoroethyl)-L-tyrosine PET: The Forschungszentrum Jülich Experience. Cancers (Basel) 2022, 14(14), 3336.

Richter N, David LS, Grothe MJ, Teipel S, Dietlein M, Tittgemeyer M, Neumaier B, Fink GR, Onur OA, Kukolja J. Age and Anterior Basal Forebrain Volume Predict the Cholinergic Deficit in Patients with Mild Cognitive Impairment due to Alzheimer's Disease. Journal of Alzheimer's Disease 2022, 86(1), 425-440.

Vázquez SM, Endepols H, Fischer T, Tawadros SG, Hohberg M, Zimmermanns B, Dietlein F, Neumaier B, Drzezga A, Dietlein M, Schomäcker K. Translational Development of a Zr-89-Labeled Inhibitor of Prostate-specific Membrane Antigen for PET Imaging in Prostate Cancer. Molecular Imaging and Biology, 2022, 24(1), 115-125.

von Eugen K, Endepols H, Drzezga A, Neumaier B, Güntürkün O, Backes H, Ströckens F. Avian neurons consume three times less glucose than mammalian neurons. Current Biology 2022, 32(19), 4306-4313.e4.

Walter HL, Pikhovych A, Endepols H, Rotthues S, Bärmann J, Backes H, Hoehn M, Wiedermann D, Neumaier B, Fink GR, Rueger MA, Schroeter M. Transcranial-Direct-Current-Stimulation Accelerates Motor Recovery After Cortical Infarction in Mice: The Interplay of Structural Cellular Responses and Functional Recovery. Neurorehabilitation and Neural Repair 2022, 36(10-11), 701-714.

Walter N, Bertram J, Drewes B, Bahutski V, Timmer M, Schütz MB, Krämer F, Neumaier F, Endepols H, Neumaier B, Zlatopolskiy BD. Convenient PET-tracer production via SuFEx 18F-fluorination of nanomolar precursor amounts. European Journal of Medicinal Chemistry 2022, 237, 114383.


Journal Articles with IREMB affiliation published (in print) in 2021:

Willmann M, Ermert J, Prante O, Hübner H, Gmeiner P, Neumaier B. Radiosynthesis and evaluation of 18F-labeled dopamine D4-receptor ligands. Nuclear Medicine and Biology 2021, 92, 43-52.

Hammes J, Bischof GN, Bohn KP, Onur Ö, Schneider A, Fliessbach K, Hönig MC, Jessen F, Neumaier B, Drzezga A, van Eimeren T. One-Stop Shop: 18F-Flortaucipir PET Differentiates Amyloid-Positive and -Negative Forms of Neurodegenerative Diseases. Journal of Nuclear Medicine 2021, 62(2), 240-246.

Renk DR, Skraban M, Bier D, Schulze A, Wabbals E, Wedekind F, Neumaier F, Neumaier B, Holschbach M. Design, synthesis and biological evaluation of Tozadenant analogues as adenosine A2A receptor ligands. European Journal of Medicinal Chemistry 2021, 214, 113214.

Neumaier F, Stoppe C, Veldeman M, Weiss M, Simon T, Hoellig A, Marx G, Clusmann H, Albanna W. Circulatory dipeptidyl peptidase 3 (cDPP3) is a potential biomarker for early detection of secondary brain injury after aneurysmal subarachnoid hemorrhage. Journal of the Neurological Sciences 2021, 422, 117333.

Apetz N, Paralikar K, Neumaier B, Drzezga A, Wiedermann D, Iyer R, Munns G, Scott E, Timmermann L, Endepols H. Towards chronic deep brain stimulation in freely moving hemiparkinsonian rats: applicability and functionality of a fully implantable stimulation system. Journal of Neural Engineering 2021, 18(3), 036018.

Willmann M, Hegger J, Neumaier B, Ermert J. Radiosynthesis and Biological Evaluation of [18F]R91150, a Selective 5-HT2A Receptor Antagonist for PET-Imaging. ACS Medicinal Chemistry Letters 2021, 12(5), 738-744.

Neumaier F, Kotliar K, Haeren RHL, Temel Y, Lüke JN, Seyam O, Lindauer U, Clusmann H, Hescheler J, Schubert GA, Schneider T, Albanna W. Retinal Vessel Responses to Flicker Stimulation Are Impaired in Cav2.3-Deficient Mice - An in-vivo Evaluation Using Retinal Vessel Analysis (RVA). Frontiers in Neurology 2021, 12, 659890.

Humpert S, Omrane MA, Urusova EA, Gremer L, Willbold D, Endepols H, Krasikova RN, Neumaier B, Zlatopolskiy BD. Rapid 18F-labeling via Pd-catalyzed S-arylation in aqueous medium. Chemical Communications (Cambridge) 2021, 57(29), 3547-3550.

Bärmann J, Walter HL, Pikhovych A, Endepols H, Fink GR, Rueger MA, Schroeter M. An analysis of the CatWalk XT and a composite score to assess neurofunctional deficits after photothrombosis in mice. Neuroscience Letters 2021, 751, 135811.

Dietlein F, Mueller P, Kobe C, Endepols H, Hohberg M, Zlatopolskiy BD, Krapf P, Heidenreich A, Neumaier B, Drzezga A, Dietlein M. [18F]-JK-PSMA-7 PET/CT Under Androgen Deprivation Therapy in Advanced Prostate Cancer. Molecular Imaging and Biology 2021, 23(2), 277-286.

Schroeder DC, Popp E, Rohleder C, Vus S, Bethencourt DP, Finke SR, Zlatopolskiy BD, Zischler J, Drzezga A, Herff H, Annecke T, Hucho T, Neumaier B, Böttiger BW, Endepols H. Positron Emission Tomography Imaging of Long-Term Expression of the 18 kDa Translocator Protein After Sudden Cardiac Arrest in Rats. Shock 2021, 55(5), 620-629.

Orlovskaya VV, Craig AS, Fedorova OS, Kuznetsova OF, Neumaier B, Krasikova RN, Zlatopolskiy BD. Production of 6-l-[18F]Fluoro-m-tyrosine in an Automated Synthesis Module for 11C-Labeling. Molecules 2021, 26(18), 5550.

Hoffmann C, Evcüman S, Neumaier F, Zlatopolskiy BD, Humpert S, Bier D, Holschbach M, Schulze A, Endepols H, Neumaier B. [18F]ALX5406: A Brain-Penetrating Prodrug for GlyT1-Specific PET Imaging. ACS Chemical Neuroscience 2021, 12(18), 3335-3346.

Neumaier F, Zlatopolskiy BD, Neumaier B. Drug Penetration into the Central Nervous System: Pharmacokinetic Concepts and In Vitro Model Systems. Pharmaceutics 2021, 13(10), 1542.

Neumaier F, Weiss M, Veldeman M, Kotliar K, Wiesmann M, Schulze-Steinen H, Höllig A, Clusmann H, Schubert GA, Albanna W. Changes in endogenous daytime melatonin levels after aneurysmal subarachnoid hemorrhage - Preliminary findings from an observational cohort study. Clinical Neurology and Neurosurgery 2021, 208, 106870.

Meinhardt MW, Pfarr S, Fouquet G, Rohleder C, Meinhardt ML, Barroso-Flores J, Hoffmann R, Jeanblanc J, Paul E, Wagner K, Hansson AC, Köhr G, Meier N, von Bohlen Und Halbach O, Bell RL, Endepols H, Neumaier B, Schönig K, Bartsch D, Naassila M, Spanagel R, Sommer WH. Psilocybin targets a common molecular mechanism for cognitive impairment and increased craving in alcoholism. Science Advances 2021, 7(47), eabh2399.

Krämer F, Gröner B, Hoffmann C, Craig A, Brugger M, Drzezga A, Timmer M, Neumaier F, Zlatopolskiy BD, Endepols H, Neumaier B. Evaluation of 3-l- and 3-d-[18F]Fluorophenylalanines as PET Tracers for Tumor Imaging. Cancers (Basel) 2021, 13(23), 6030.

Song M, Scheifele M, Barthel H, van Eimeren T, Beyer L, Marek K, Eckenweber F, Palleis C, Kaiser L, Finze A, Kern M, Nitschmann A, Biechele G, Katzdobler S, Bischof G, Hammes J, Jessen F, Saur D, Schroeter ML, Rumpf JJ, Rullmann M, Schildan A, Patt M, Neumaier B, Stephens AW, Rauchmann BS, Perneczky R, Levin J, Classen J, Höglinger GU, Bartenstein P, Boening G, Ziegler S, Villemagne V, Drzezga A, Seibyl J, Sabri O, Brendel M; German Imaging Initiative for Tauopathies (GII4T). Feasibility of short imaging protocols for [18F]PI-2620 tau-PET in progressive supranuclear palsy. European Journal of Nuclear Medicine and Molecular Imaging 2021, 48(12), 3872-3885.


Journal Articles with IREMB affiliation published (in print) in 2020:

Dietlein F, Hohberg M, Kobe C, Zlatopolskiy BD, Krapf P, Endepols H, Täger P, Hammes J, Heidenreich A, Neumaier B, Drzezga A, Dietlein M. An 18F-Labeled PSMA Ligand for PET/CT of Prostate Cancer: First-in-Humans Observational Study and Clinical Experience with 18F-JK-PSMA-7 During the First Year of Application. Journal of Nuclear Medicine 2020, 61(2), 202-209.

Dietlein F, Kobe C, Hohberg M, Zlatopolskiy BD, Krapf P, Endepols H, Täger P, Hammes J, Heidenreich A, Persigehl T, Neumaier B, Drzezga A, Dietlein M. Intraindividual Comparison of 18F-PSMA-1007 with Renally Excreted PSMA Ligands for PSMA PET Imaging in Patients with Relapsed Prostate Cancer. Journal of Nuclear Medicine 2020, 61(5), 729-734.

Rohleder C, Pahlisch F, Graf R, Endepols H, Leweke FM. Different pharmaceutical preparations of Δ9 -tetrahydrocannabinol differentially affect its behavioral effects in rats. Addiction Biology 2020, 25(3), e12745.

Zlatopolskiy BD, Neumaier F, Rüngeler T, Drewes B, Kolks N, Neumaier B. Preparation of a First 18F-Labeled Agonist for M1 Muscarinic Acetylcholine Receptors. Molecules 2020, 25(12), 2880.

Craig A, Kolks N, Urusova EA, Zischler J, Brugger M, Endepols H, Neumaier B, Zlatopolskiy BD. Preparation of labeled aromatic amino acids via late-stage 18F-fluorination of chiral nickel and copper complexes. Chemical Communications (Cambridge) 2020, 56(66), 9505-9508.

Cui D, Mesaros A, Burdeos G, Voigt I, Giavalisco P, Hinze Y, Purrio M, Neumaier B, Drzezga A, Obata Y, Endepols H, Xu X. Dnmt3a2/Dnmt3L Overexpression in the Dopaminergic System of Mice Increases Exercise Behavior through Signaling Changes in the Hypothalamus. International Journal of Molecular Sciences 2020, 21(17), 6297.

Zlatopolskiy BD, Endepols H, Krasikova RN, Fedorova OS, Ermert J, Neumaier B. 11C- and 18F-labelled tryptophans as PET-tracers for imaging of altered tryptophan metabolism in age-associated disorders.  Russian Chemical Reviews 2020, 89(9), 879–896.

Bier D, Holschbach M, Wedekind F, Sihver W, Drewes B, Schulze A, Neumaier F, Neumaier B, Bauer A. Preparation of 5-[131I]iodotubercidin for the detection of adenosine kinase. Journal of Radioanalytical and Nuclear Chemistry 2020, 326, 1691–1697.

Bier D, Schulze A, Holschbach M, Neumaier B, Baumann A. Development and Evaluation of a Versatile Receptor-Ligand Binding Assay Using Cell Membrane Preparations Embedded in an Agarose Gel Matrix and Evaluation with the Human Adenosine A1 Receptor. Assay and Drug Development Technologies 2020, 18(7), 328-340.

Beyer L, Nitschmann A, Barthel H, van Eimeren T, Unterrainer M, Sauerbeck J, Marek K, Song M, Palleis C, Respondek G, Hammes J, Barbe MT, Onur Ö, Jessen F, Saur D, Schroeter ML, Rumpf JJ, Rullmann M, Schildan A, Patt M, Neumaier B, Barret O, Madonia J, Russell DS, Stephens AW, Roeber S, Herms J, Bötzel K, Levin J, Classen J, Höglinger GU, Bartenstein P, Villemagne V, Drzezga A, Seibyl J, Sabri O, Brendel M. Early-phase [18F]PI-2620 tau-PET imaging as a surrogate marker of neuronal injury. European Journal of Nuclear Medicine and Molecular Imaging 2020, 47(12), 2911-2922.

Richter N, Bischof GN, Dronse J, Nellessen N, Neumaier B, Langen KJ, Drzezga A, Fink GR, van Eimeren T, Kukolja J, Onur OA. Entorhinal Tau Predicts Hippocampal Activation and Memory Deficits in Alzheimer's Disease. Journal of Alzheimer's Disease 2020, 78(4), 1601-1614.

Neumaier F, Zlatopolskiy BD, Neumaier B. Nuclear Medicine in Times of COVID-19: How Radiopharmaceuticals Could Help to Fight the Current and Future Pandemics. Pharmaceutics 2020, 12(12), 1247.

2015 - 2020

Hoenig, M. C.; Bischof, G. N.; Onur, Ö. A.; Kukolja, J.; Jessen, F.; Fliessbach, K.; Neumaier, B.; Fink, G. R.; Kalbe, E.; Drzezga, A.; van Eimeren, T.; Alzheimer’s Disease Neuroimaging Initiative. Level of Education Mitigates the Impact of Tau Pathology on Neuronal Function. Eur. J. Nucl. Med. Mol. Imaging 2019.

Zlatopolskiy, B.; Zischler, J.; Schäfer, D.; Urusova, E.; Guliyev, M.; Bannykh, O.; Endepols, H.; Neumaier, B. Discovery of 7-[F]Fluorotryptophan as a Novel Positron Emission Tomography (PET) Probe for the Visualization of Tryptophan Metabolism in Vivo. J Med Chem. 201861 (1), 189–206.

Endepols, H.; Mottaghy, F. M.; Simsekyilmaz, S.; Bucerius, J.; Vogt, F.; Winz, O.; Richarz, R.; Krapf, P.; Neumaier, B.; Zlatopolskiy, B. D.; Morgenroth, A. In Vivo Molecular Imaging of Glutamate Carboxypeptidase II Expression in Re-Endothelialisation after Percutaneous Balloon Denudation in a Rat Model. Sci Rep 20188 (1), 7411.

Richter, N.; Beckers, N.; Onur, O. A.; Dietlein, M.; Tittgemeyer, M.; Kracht, L.; Neumaier, B.; Fink, G. R.; Kukolja, J. Effect of Cholinergic Treatment Depends on Cholinergic Integrity in Early Alzheimer’s Disease. Brain 2018141 (3), 903–915.

Hoenig, M. C.; Bischof, G. N.; Seemiller, J.; Hammes, J.; Kukolja, J.; Onur, Ö. A.; Jessen, F.; Fliessbach, K.; Neumaier, B.; Fink, G. R.; van Eimeren, T.; Drzezga, A. Networks of Tau Distribution in Alzheimer’s Disease. Brain 2018141 (2), 568–581.

Zischler, J.; Kolks, N.; Modemann, D.; Neumaier, B.; Zlatopolskiy, B. D. Alcohol-Enhanced Cu-Mediated Radiofluorination.Chemistry 201723 (14), 3251–3256.

Dronse, J.; Fliessbach, K.; Bischof, G. N.; von Reutern, B.; Faber, J.; Hammes, J.; Kuhnert, G.; Neumaier, B.; Onur, O. A.; Kukolja, J.; van Eimeren, T.; Jessen, F.; Fink, G. R.; Klockgether, T.; Drzezga, A. In Vivo Patterns of Tau Pathology, Amyloid-β Burden, and Neuronal Dysfunction in Clinical Variants of Alzheimer’s Disease. J. Alzheimers Dis. 201755 (2), 465–471.

Dietlein, M.; Kobe, C.; Kuhnert, G.; Stockter, S.; Fischer, T.; Schomäcker, K.; Schmidt, M.; Dietlein, F.; Zlatopolskiy, B. D.; Krapf, P.; Richarz, R.; Neubauer, S.; Drzezga, A.; Neumaier, B. Comparison of [18F]DCFPyL and [68Ga]Ga-PSMA-HBED-CC for PSMA-PET Imaging in Patients with Relapsed Prostate Cancer. Mol Imaging Biol 201517 (4), 575–584.

Zlatopolskiy, B. D.; Zischler, J.; Krapf, P.; Zarrad, F.; Urusova, E. A.; Kordys, E.; Endepols, H.; Neumaier, B. Copper-Mediated Aromatic Radiofluorination Revisited: Efficient Production of PET Tracers on a Preparative Scale. Chemistry – A European Journal 2015,21 (15), 5972–5979.

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